"Most Profitable Home-based Businesses" in America 2008 - Forbes Magazine
1.  Securities and Commodity Brokers 
  Average Pretax Profit Margin: 14% 
2. Software Publishers 
  Average Pretax Profit Margin: 14% 
3. Artists, Writers, Performers 
  Average Pretax Profit Margin: 13% 
4. Insurance Agents and Brokers 
  Average Pretax Profit Margin: 13% 
5. Specialized Design Services 
  Average Pretax Profit Margin: 11% 
6. Consulting Services 
  Average Pretax Profit Margin: 10% 
7. Personal and Household Goods Repair and Maintenance 
  Average Pretax Profit Margin: 10% 
8. Offices of Real Estate Agents and Brokers 
  Average Pretax Profit Margin: 9% 
9. Electronic and Precision Equipment Repair and Maintenance 
  Average Pretax Profit Margin: 9% 
10. Grant Making and Giving Services 
  Average Pretax Profit Margin: 8% 
My apologies for the uneven type which I cannot seem to correct.
The only one that surprised me is #7, where shoe repair shops are cited as the next big “home-based business”!
Further information is at the article here:
http://www.forbes.com/2008/10/14/profitable-home-businesses-ent-fin-cx_mf_1014mostprofitablehomebiz.html?feed=rss_news